LONG-TERM EFFECTS OF PROPYLTHIOURACIL-INDUCED NEONATAL HYPO-THYROIDISM

被引：41

作者：

SCHALOCK, RL ^{[1
]}

BROWN, WJ ^{[1
]}

SMITH, RL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT PATHOL,DIV NEUROPATHOL,LOS ANGELES,CA 90024

来源：

DEVELOPMENTAL PSYCHOBIOLOGY | 1979年 / 12卷 / 03期

关键词：

D O I：

10.1002/dev.420120302

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypothyroidism was induced in neonatal Sprague‐Dawley rats by adding propylthiouracil to the lactating female's food and water. Behavioral evaluation on a 6‐item battery occurred from 70 to 114 days of age. Results indicated long‐lasting behavioral changes in the neonatal hypothyroid animals characterized by increased activity and decreased performance on avoidance and escape learning. Serum thyroxine levels were reduced in the hypothyroid animals throughout the 120‐day period. Experimental animals also had fewer synaptic contacts in the cerebellar cortex when analyzed at 90 days of age. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：187 / 199

页数：13

共 25 条

[1]

Bakke JL, 1975, PERINATAL THYROID PH, P79

[2] BIOCHEMICAL EFFECTS OF THYROID DEFICIENCY ON DEVELOPING BRAIN [J].

BALAZS, R ;

KOVACS, S ;

TEICHGRABER, P ;

COCKS, WA ;

EAYRS, JT .

JOURNAL OF NEUROCHEMISTRY, 1968, 15 (11) :1335-+

[3] OPERANT BEHAVIOR OF PRE AND POST PUBERTAL RATS IRRADIATED WITH I131 IN LAST TRIMESTER OF GESTATION [J].

BOGDANOVE, LH ;

DOODY, A ;

NADACKAPADAM, X .

EXPERIENTIA, 1971, 27 (08) :907-+

[4] INHIBITION OF CEREBELLAR DENDRITE DEVELOPMENT IN NEONATAL THYROID-DEFICIENCY [J].

BROWN, WJ ;

VERITY, MA ;

SMITH, RL .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1976, 2 (03) :191-207

[5]

BROWN WJ, 1974, J NEUROPATH EXP NEUR, V33, P562

[6] RADIOIMMUNOASSAY FOR MEASUREMENT OF THYROXINE IN UNEXTRACTED SERUM [J].

CHOPRA, IJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 34 (06) :938-+

[7] CRETINISM IN RATS . ENDURING BEHAVIORAL DEFICIT INDUCED BY TRICYANOAMINOPROPENE [J].

DAVENPOR.JW .

SCIENCE, 1970, 167 (3920) :1007-&

[8] ENVIRONMENTAL STIMULATION REDUCES LEARNING DEFICITS IN EXPERIMENTAL CRETINISM [J].

DAVENPORT, JW ;

GONZALEZ, LM ;

CAREY, JC ;

BISHOP, SB ;

HAGQUIST, WW .

SCIENCE, 1976, 191 (4227) :578-579

[9] HYPOTHYROIDISM - LEARNING DEFICIT INDUCED IN RATS BY EARLY EXPOSURE TO THIOURACIL [J].

DAVENPORT, JW ;

DORCEY, TP .

HORMONES AND BEHAVIOR, 1972, 3 (02) :97-+

[10] LEARNING AND HORMONE ACTIVITY .1. EFFECTS OF THYROID LEVELS UPON THE ACQUISITION AND EXTINCTION OF AN OPERANT RESPONSE [J].

DENENBERG, VH ;

MYERS, RD .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1958, 51 (02) :213-219

← 1 2 3 →