2 NEW 9,11-SECOSTEROLS FROM THE MARINE SPONGE SPONGIA-OFFICINALIS - SYNTHESIS OF 9,11-SECO-3-BETA,6-ALPHA,11-TRIHYDROXY-5-ALPHA-CHOLEST-7-EN-9-ONE

被引：32

作者：

MIGLIUOLO, A ^{[1
]}

PICCIALLI, V ^{[1
]}

SICA, D ^{[1
]}

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM ORGAN & BIOL,VIA MEZZOCANNONE 16,I-80134 NAPLES,ITALY

来源：

STEROIDS | 1992年 / 57卷 / 07期

关键词：

STEROLS; 9,11-SECOSTEROLS; 9,11-SECO-3-BETA,6-ALPHA,11-TRIHYDROXY-5-ALPHA-CHOLEST-7-EN-9-ONE; 9,11-SECO-3-BETA,6-ALPHA,11-TRIHYDROXY-24-METHYLENE-5-ALPHA-CHOLEST-7-EN-9-ONE; SYNTHESIS; H-1 NUCLEAR MAGNETIC RESONANCE; C-13 NUCLEAR MAGNETIC RESONANCE; 2-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE CORRELATION SPECTROSCOPY;

D O I：

10.1016/0039-128X(92)90054-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new 9,11-secosterol, 9,11-seco-3-beta,6-alpha,11-trihydroxy-5-alpha-cholest-7-en-9-one (2) and 9,11-seco-3-beta,6-alpha,11-trihydroxy-24-methylene-5-alpha-cholest-7-en-9-one (3), have been isolated from the marine sponge Spongia officinalis and their structures elucidated by analysis of spectral data including H-1 nuclear magnetic resonance correlation spectroscopy (COSY) experiments. Partial synthesis of 2 starting from 3-beta,6-alpha-dihydroxy-9-oxo-9,11-seco-5-alpha-cholest-7-en-11-al(1) confirmed the structure assignment.

引用

页码：344 / 347

页数：4

共 7 条

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