A NOVEL ENANTIOSELECTIVE PREPARATION OF ALPHA-FLUORO-BETA-KETO ACIDS

被引：25

作者：

IWAOKA, T

MUROHASHI, T

SATO, M

KANEKO, C

机构：

[1] Pharmaceutical Institute, Tohoku University, Sendai, 980, Aobayama

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)86035-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A two-step method for the enantioselective preparation of alpha-fluorinated beta-keto acids from 1,3-dioxin-4-ones having l-menthone as the chiral auxiliary at the 2-position is described. The method consists of fluorination of the dioxinones by molecular fluorine and solvolytic cleavage of the acetal function.

引用

页码：1025 / 1028

页数：4

共 20 条

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