RAPID GENOMIC EVOLUTION OF A NONVIRULENT COXSACKIEVIRUS B3 IN SELENIUM-DEFICIENT MICE RESULTS IN SELECTION OF IDENTICAL VIRULENT ISOLATES

被引：292

作者：

BECK, MA ^{[1
]}

SHI, Q ^{[1
]}

MORRIS, VC ^{[1
]}

LEVANDER, OA ^{[1
]}

机构：

[1] USDA ARS,BELTSVILLE HUMAN NUTR RES CTR,NUTRIENT REQUIREMENTS & FUNCT LAB,BELTSVILLE,MD 20705

来源：

NATURE MEDICINE | 1995年 / 1卷 / 05期

关键词：

D O I：

10.1038/nm0595-433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous work from our laboratory demonstrated that selenium deficiency in the mouse allows a normally benign (amyocarditic) cloned and sequenced Coxsackievirus to cause significant heart damage. Furthermore, Coxsackievirus recovered from the hearts of selenium-deficient mice inoculated into selenium-adequate mice still induced significant heart damage, suggesting that the amyocarditic Coxsackievirus had mutated to a virulent phenotype. Here we report that sequence analysis revealed six nucleotide changes between the virulent virus recovered from the selenium-deficient host and the avirulent input virus. These nucleotide changes are consistent with known differences in base composition between virulent and avirulent strains of Coxsackievirus. To the best of our knowledge, this is the first report of a specific nutritional deficiency driving changes in a viral genome, permitting an avirulent virus to acquire virulence due to genetic mutation.

引用

页码：433 / 436

页数：4