THE ROLE OF IGA ANTI-HLA CLASS-I ANTIBODIES IN KIDNEY-TRANSPLANT SURVIVAL

被引：30

作者：

KOKA, P ^{[1
]}

CHIA, D ^{[1
]}

TERASAKI, PI ^{[1
]}

CHAN, H ^{[1
]}

CHIA, J ^{[1
]}

OZAWA, M ^{[1
]}

LIM, E ^{[1
]}

机构：

[1] UNIV PHILIPPINES, COLL MED, MANILA, PHILIPPINES

来源：

TRANSPLANTATION | 1993年 / 56卷 / 01期

关键词：

D O I：

10.1097/00007890-199307000-00038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The unusually high 88% one-year cadaver kidney graft survival rate in patients with IgA nephropathy (IgAN) prompted us to investigate the influence of IgA anti-HLA class I antibodies on subsequent graft survival. We found that patients with various original diseases with IgA antibodies to the HLA molecule had high 91% one-year graft survival compared with 58% one-year survival for those who did not have preformed IgA antibodies against the HLA molecule prior to transplantation (P<0.0005). The IgA antibodies were detected by reaction with class I HLA molecules isolated by capture with monoclonal antibody and detected with an enzyme-linked immunosorbent assay. In contrast, IgG antibodies to the HLA molecule resulted in a lower one-year graft survival rate (74%) than in those patients without IgG antibodies (87%) (p=0.08). IgA antibodies to the HLA molecule, when present, tended to react at a high frequency on a random lymphocyte panel. These findings suggest that sensitization resulting in IgA anti-HLA antibodies may counteract the deleterious effect of an IgG antibody response in clinical kidney transplantation.

引用

页码：207 / 211

页数：5

共 14 条

[11] DISCRIMINATION OF ANTIBODIES AGAINST ANTIGENS OF DIFFERENT MHC LOCI IN HUMAN-SERA BY MONOCLONAL-ANTIBODY SPECIFIC IMMOBILIZATION OF LEUKOCYTE ANTIGENS [J].