MELIAVOLKENIN, A NEW BIOACTIVE TRITERPENOID FROM MELIA-VOLKENSII (MELIACEAE)

被引：15

作者：

ZENG, L

GU, ZM

CHANG, CJ

WOOD, KV

MCLAUGHLIN, JL

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] PURDUE UNIV,SCH SCI,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 04期

关键词：

D O I：

10.1016/0968-0896(95)00034-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Meliavolkenin, a new triterpene with an apotirucallane skeleton, has been isolated from the root bark of Melia volkensii (Meliaceae) by bioactivity-directed fractionation using the brine shrimp lethality test. The structure has been elucidated using spectral and chemical data. The relative stereochemistries were determined by reduction and acetonide derivations, and the ring conformations were analyzed using the results of NOESY experiments. Meliavolkenin was bioactive in the brine shrimp lethality test and gave moderate cytotoxicities against three human solid tumor lines.

引用

页码：383 / 390

页数：8

共 13 条

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