Therapeutic Hypothermia for Neuroprotection: History, Mechanisms, Risks, and Clinical Applications
被引:92
作者:
Karnatovskaia, Lioudmila V.
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机构:
Mayo Clin, Dept Pulm, Jacksonville, FL 32224 USA
Mayo Clin, Dept Crit Care, Jacksonville, FL 32224 USAMayo Clin, Dept Pulm, Jacksonville, FL 32224 USA
Karnatovskaia, Lioudmila V.
[1
,2
]
Wartenberg, Katja E.
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机构:
Martin Luther Univ Halle Wittenberg, Dept Neurol, Halle, GermanyMayo Clin, Dept Pulm, Jacksonville, FL 32224 USA
Wartenberg, Katja E.
[3
]
Freeman, William D.
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机构:
Mayo Clin, Dept Crit Care, Jacksonville, FL 32224 USA
Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA
Mayo Clin, Dept Neurosurg, Jacksonville, FL 32224 USAMayo Clin, Dept Pulm, Jacksonville, FL 32224 USA
Freeman, William D.
[2
,4
,5
]
机构:
[1] Mayo Clin, Dept Pulm, Jacksonville, FL 32224 USA
[2] Mayo Clin, Dept Crit Care, Jacksonville, FL 32224 USA
[3] Martin Luther Univ Halle Wittenberg, Dept Neurol, Halle, Germany
[4] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA
[5] Mayo Clin, Dept Neurosurg, Jacksonville, FL 32224 USA
The earliest recorded application of therapeutic hypothermia in medicine spans about 5000 years; however, its use has become widespread since 2002, following the demonstration of both safety and efficacy of regimens requiring only a mild (32 degrees C-35 degrees C) degree of cooling after cardiac arrest. We review the mechanisms by which hypothermia confers neuroprotection as well as its physiological effects by body system and its associated risks. With regard to clinical applications, we present evidence on the role of hypothermia in traumatic brain injury, intracranial pressure elevation, stroke, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and neonatal peripartum encephalopathy. Based on the current knowledge and areas undergoing or in need of further exploration, we feel that therapeutic hypothermia holds promise in the treatment of patients with various forms of neurologic injury; however, additional quality studies are needed before its true role is fully known.
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, TaiwanWeil Inst Crit Care Med, Rancho Mirage, CA USA
Tsai, Min-Shan
Barbut, Denise
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机构:
Benechill Inc, San Diego, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Barbut, Denise
Wang, Hao
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机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Wang, Hao
Guan, Jun
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Weil Inst Crit Care Med, Rancho Mirage, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Guan, Jun
Sun, Shijie
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机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Sun, Shijie
Inderbitzen, Becky
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机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Benechill Inc, San Diego, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Inderbitzen, Becky
Weil, Max Harry
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h-index: 0
机构:
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Weil, Max Harry
Tang, Wanchun
论文数: 0引用数: 0
h-index: 0
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, TaiwanWeil Inst Crit Care Med, Rancho Mirage, CA USA
Tsai, Min-Shan
Barbut, Denise
论文数: 0引用数: 0
h-index: 0
机构:
Benechill Inc, San Diego, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Barbut, Denise
Wang, Hao
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机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Wang, Hao
Guan, Jun
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h-index: 0
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Guan, Jun
Sun, Shijie
论文数: 0引用数: 0
h-index: 0
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Sun, Shijie
Inderbitzen, Becky
论文数: 0引用数: 0
h-index: 0
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Benechill Inc, San Diego, CA USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Inderbitzen, Becky
Weil, Max Harry
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA
Weil, Max Harry
Tang, Wanchun
论文数: 0引用数: 0
h-index: 0
机构:
Weil Inst Crit Care Med, Rancho Mirage, CA USA
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USAWeil Inst Crit Care Med, Rancho Mirage, CA USA