CLINICAL PHARMACOKINETICS AFTER REPEATED INTRAPLEURAL BUPIVACAINE ADMINISTRATION

被引：4

作者：

DEBRUYNE, D ^{[1
]}

MOULIN, MA ^{[1
]}

TARTIERE, J ^{[1
]}

BIGOT, MC ^{[1
]}

GERARD, JL ^{[1
]}

BRICARD, H ^{[1
]}

机构：

[1] CTR HOSP REG & UNIV CAEN,DEPT ANAESTHESIOL,F-14033 CAEN,FRANCE

来源：

CLINICAL PHARMACOKINETICS | 1990年 / 18卷 / 03期

关键词：

D O I：

10.2165/00003088-199018030-00005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Patients (n = 14) who underwent thoracotomy during surgery of the oesophagus for cancer received an initial intrapleural dose of 10ml bupivacaine hydrochloride 2.5 mg/ml followed by repeated administration every 8 hours from the first to the fourth postoperative day. The mean ( ±SD) peak plasma drug concentration (Cmax) [352 ± 120 μg/L], time to peak (tmax) [0.83 ± 0.51h], and first-order absorption rate constant (ka) [5.46 ± 4.95 h−1] after the twelfth dose were significantly different from the Cmax (206 ± 81 μg/L). tmax (1.8 ± 1.2h), and ka (1.8 ± 1.47 h−1) determined after the first dose. Halflife (3.5 ± 2.2h) and mean concentration (204 ± 105 μg/L) were not significantly different on the fourth day from those on the first (4.1 ± 2.6h and 142 ± 71 μg/L, respectively). No sharp peak corresponding to sytemic toxicity and no accumulation could be expected with these low doses, administered at short intervals and providing good pain relief in this surgical series. © 1990, ADIS Press Limited. All rights reserved.

引用

页码：240 / 244

页数：5

共 18 条

[11]

REIESTAD F, 1986, ANESTHESIOLOGY, V65, pA204

[12] EFFECT OF INTRAABDOMINAL BUPIVACAINE INSTILLATION ON POSTOPERATIVE COLONIC MOTILITY [J].

RIMBACK, G ;

CASSUTO, J ;

FAXEN, A ;

HOGSTROM, S ;

WALLIN, G ;

TOLLESSON, PO .

GUT, 1986, 27 (02) :170-175

[13] INTRAPLEURAL BUPIVACAINE - A KINETIC AND DYNAMIC EVALUATION [J].

SELTZER, JL ;

LARIJANI, GE ;

GOLDBERG, ME ;

MARR, AT .

ANESTHESIOLOGY, 1987, 67 (05) :798-800

[14]

STROMSKAG KE, 1988, ANESTH ANALG, V67, P430

[15]

TUCKER GT, 1975, BRIT J ANAESTH, V47, P213

[16] CLINICAL PHARMACOKINETICS OF LOCAL-ANESTHETICS [J].

TUCKER, GT ;

MATHER, LE .

CLINICAL PHARMACOKINETICS, 1979, 4 (04) :241-278

[17]

WAGNER JG, 1975, FUNDAMENTALS CLIN PH

[18] BUPIVACAINE LEVELS IN PLASMA AND CEREBROSPINAL FLUID FOLLOWING PERIDURAL ADMINISTRATION [J].

WILKINSON, GR ;

LUND, PC .

ANESTHESIOLOGY, 1970, 33 (05) :482-+

← 1 2 →