KINDLING-INDUCED EPILEPSY ALTERS CALCIUM CURRENTS IN GRANULE CELLS OF RAT HIPPOCAMPAL SLICES

被引：51

作者：

MODY, I ^{[1
]}

REYNOLDS, JN ^{[1
]}

SALTER, MW ^{[1
]}

CARLEN, PL ^{[1
]}

MACDONALD, JF ^{[1
]}

机构：

[1] TORONTO GEN HOSP,PLAYFAIR NEUROSCI UNIT,TORONTO M5G 1L7,ONTARIO,CANADA

来源：

BRAIN RESEARCH | 1990年 / 531卷 / 1-2期

关键词：

Calcium buffering; Calcium current; Dentate gyrus; Epilepsy; Ethylene glycol bis(β-aminoethyl ether); Hippocampus; Kindling; N; N′; N′-Tetraacetic acid (EGTA); Voltage-clamp;

D O I：

10.1016/0006-8993(90)90761-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single electrode voltage-clamp recordings were obtained from dentate gyrus granule cells (GCs) in hippocampal slices of control and commissurally kindled rats. Two types of calcium currents, a transient and a sustained current, were studied in control and kindled neurons. The threshold of the transient calcium current was lowered in kindled GCs. The sustained calcium current was absent in kindled neurons but it could be restored by the intracellular administration of the calcium chelator EGTA. Our findings are consistent with the hypothesis that the loss of an intraneuronal calcium binding protein (Calbindin-D28K; CaBP) reduces the intraneuronal calcium buffering capacity in kindled neurons and results in the enhanced calcium-dependent inactivation of sustained calcium currents. © 1990.

引用

页码：88 / 94

页数：7

共 35 条

[1] A SPATIAL-TEMPORAL MODEL OF CELL ACTIVATION [J].

ALKON, DL ;

RASMUSSEN, H .

SCIENCE, 1988, 239 (4843) :998-1005

[2] REDUCTION OF RAT HIPPOCAMPAL CALCIUM-BINDING PROTEIN FOLLOWING COMMISSURAL, AMYGDALA, SEPTAL, PERFORANT PATH, AND OLFACTORY-BULB KINDLING [J].

BAIMBRIDGE, KG ;

MODY, I ;

MILLER, JJ .

EPILEPSIA, 1985, 26 (05) :460-465

[3] HIPPOCAMPAL CALCIUM-BINDING PROTEIN DURING COMMISSURAL KINDLING-INDUCED EPILEPTOGENESIS - PROGRESSIVE DECLINE AND EFFECTS OF ANTICONVULSANTS [J].

BAIMBRIDGE, KG ;

MILLER, JJ .

BRAIN RESEARCH, 1984, 324 (01) :85-90

[4] PHARMACOLOGICAL AND ANATOMICAL SEPARATION OF CALCIUM CURRENTS IN RAT DENTATE GRANULE NEURONS INVITRO [J].

BLAXTER, TJ ;

CARLEN, PL ;

NIESEN, C .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 412 :93-112

[5] DEPOLARIZATION ELICITS 2 DISTINCT CALCIUM CURRENTS IN VERTEBRATE SENSORY NEURONS [J].

BOSSU, JL ;

FELTZ, A ;

THOMANN, JM .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1985, 403 (04) :360-368

[6] SUSTAINED DENDRITIC GRADIENTS OF CA-2+ INDUCED BY EXCITATORY AMINO-ACIDS IN CA1 HIPPOCAMPAL-NEURONS [J].

CONNOR, JA ;

WADMAN, WJ ;

HOCKBERGER, PE ;

WONG, RKS .

SCIENCE, 1988, 240 (4852) :649-653

[7]

DeLorenzo R J, 1986, Adv Neurol, V44, P435

[8] N-METHYL ASPARTATE ACTIVATES VOLTAGE-DEPENDENT CALCIUM CONDUCTANCE IN RAT HIPPOCAMPAL PYRAMIDAL CELLS [J].

DINGLEDINE, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 343 (OCT) :385-405

[9] KINDLING STIMULATION INDUCES C-FOS PROTEIN(S) IN GRANULE CELLS OF THE RAT DENTATE GYRUS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

NATURE, 1987, 329 (6138) :441-442

[10] EFFECT OF INTERNAL CALCIUM-CONCENTRATION ON CALCIUM CURRENTS IN RAT SENSORY NEURONS [J].

DUPONT, JL ;

BOSSU, JL ;

FELTZ, A .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1986, 406 (04) :433-435

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