KINDLING-INDUCED EPILEPSY ALTERS CALCIUM CURRENTS IN GRANULE CELLS OF RAT HIPPOCAMPAL SLICES

被引：51

作者：

MODY, I ^{[1
]}

REYNOLDS, JN ^{[1
]}

SALTER, MW ^{[1
]}

CARLEN, PL ^{[1
]}

MACDONALD, JF ^{[1
]}

机构：

[1] TORONTO GEN HOSP,PLAYFAIR NEUROSCI UNIT,TORONTO M5G 1L7,ONTARIO,CANADA

来源：

BRAIN RESEARCH | 1990年 / 531卷 / 1-2期

关键词：

Calcium buffering; Calcium current; Dentate gyrus; Epilepsy; Ethylene glycol bis(β-aminoethyl ether); Hippocampus; Kindling; N; N′; N′-Tetraacetic acid (EGTA); Voltage-clamp;

D O I：

10.1016/0006-8993(90)90761-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single electrode voltage-clamp recordings were obtained from dentate gyrus granule cells (GCs) in hippocampal slices of control and commissurally kindled rats. Two types of calcium currents, a transient and a sustained current, were studied in control and kindled neurons. The threshold of the transient calcium current was lowered in kindled GCs. The sustained calcium current was absent in kindled neurons but it could be restored by the intracellular administration of the calcium chelator EGTA. Our findings are consistent with the hypothesis that the loss of an intraneuronal calcium binding protein (Calbindin-D28K; CaBP) reduces the intraneuronal calcium buffering capacity in kindled neurons and results in the enhanced calcium-dependent inactivation of sustained calcium currents. © 1990.

引用

页码：88 / 94

页数：7

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