共 21 条
[21]
WIEBE VJ, 1988, REV INFECT DIS, V10, P1097
COMPARATIVE EFFICACIES OF AMPHOTERICIN-B LIPID COMPLEX AND AMPHOTERICIN-B DEOXYCHOLATE SUSPENSION AGAINST MURINE BLASTOMYCOSIS
被引：50
作者：
CLEMONS, KV
STEVENS, DA
机构：
[1] CALIF INST MED RES, SAN JOSE, CA 95128 USA
[2] STANFORD UNIV, DEPT MED, DIV INFECT DIS, STANFORD, CA 94305 USA
关键词：
D O I：
10.1128/AAC.35.10.2144
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ;
100705 ;
摘要：
Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P < 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was not toxic and superior in efficacy (P < 0.001) to 2.0 mg of Fungizone per kg (a toxic dose), and it cleared all animals of infection. Lipid complex is an effective therapy for murine blastomycosis.
引用
收藏
页码：2144 / 2146
页数：3
相关论文