DEPLETION OF COMPLEMENT AND EFFECTS ON PASSIVE TRANSFER OF RESISTANCE TO INFECTION WITH BORRELIA-BURGDORFERI

被引：21

作者：

SCHMITZ, JL

LOVRICH, SD

CALLISTER, SM

SCHELL, RF

机构：

[1] UNIV WISCONSIN, WISCONSIN STATE LAB HYG, MADISON, WI 53706 USA

[2] GUNDERSON MED FDN, LA CROSSE, WI 54601 USA

[3] UNIV WISCONSIN, DEPT BACTERIOL, MADISON, WI 53706 USA

[4] UNIV WISCONSIN, DEPT MED MICROBIOL, MADISON, WI 53706 USA

[5] UNIV WISCONSIN, DEPT IMMUNOL, MADISON, WI 53706 USA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 10期

关键词：

D O I：

10.1128/IAI.59.10.3815-3818.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When irradiated hamsters are passively immunized with immune serum before challenge with Borrelia burgdorferi, they are completely protected from arthritis and infection. The complement dependency of this protection was addressed by treating hamsters with cobra venom factor. Depletion of complement abrogated the ability of immune serum obtained 1 and 10 weeks after infection to confer complete protection. By contrast, depletion of complement had no effect on the ability of 3-week immune serum to confer protection. These results suggest that complement-dependent, and possibly complement-independent, antibodies are important for preventing the induction of Lyme arthritis.

引用

页码：3815 / 3818

页数：4

共 31 条

[21]

RUDDY S, 1986, MANUAL CLIN LABORATO, P179

[22] MONOCLONAL-ANTIBODIES SPECIFIC FOR THE OUTER SURFACE PROTEIN-A (OSPA) OF BORRELIA-BURGDORFERI PREVENT LYME BORRELIOSIS IN SEVERE COMBINED IMMUNODEFICIENCY (SCID) MICE [J].