FILM-FORMING POLYMERS FOR COLONIC DRUG-DELIVERY .1. SYNTHESIS AND PHYSICAL AND CHEMICAL-PROPERTIES OF METHYL-DERIVATIVES OF EUDRAGIT-S

被引：39

作者：

PEETERS, R ^{[1
]}

KINGET, R ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,GALEN & CLIN PHARM LAB,CAMPUS GASTHUISBERG,B-3000 LOUVAIN,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 94卷 / 1-3期

关键词：

COATING; COLON; DRUG DELIVERY; METHYLPOLYMETHACRYLATE;

D O I：

10.1016/0378-5173(93)90016-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several methylated derivatives of Eudragit S with different degrees of substitution were prepared for evaluation as potential coatings for colon delivery. Water vapor transmission, in vitro dissolution and stability in function of pH were investigated using the technique of isolated films. The data presented demonstrate relative differences in physico-chemical characteristics due to differences in degree of substitution. The relationship of degree of substitution and dissolution pH is direct and inverse for moisture diffusion rate. In the second part of the in vitro study the coating properties of the methyl substitutes of Eudragit S were investigated after application on hard gelatin capsules. The disintegration time of the coated capsules and the release of caffeine at pH 7.5 were in very good agreement with the results obtained with isolated films.

引用

页码：125 / 134

页数：10

共 18 条

[11]

Mardini H A, 1987, Gut, V28, P1084, DOI 10.1136/gut.28.9.1084

[12]

PRADNY M, 1990, MAKROMOL CHEM, V191, P1887

[13] A NEW APPROACH TO THE ORAL-ADMINISTRATION OF INSULIN AND OTHER PEPTIDE DRUGS [J].

SAFFRAN, M ;

KUMAR, GS ;

SAVARIAR, C ;

BURNHAM, JC ;

WILLIAMS, F ;

NECKERS, DC .

SCIENCE, 1986, 233 (4768) :1081-1084

[14]

SPITAEL J, 1979, ACTA PHARM TECHNOL S, V7, P163

[15]

TERHORST HJ, 1989, PHARM WEEKBLAD, V124, P530

[16] QUINOLONES AND COLONIZATION RESISTANCE IN HUMAN VOLUNTEERS [J].

VANSAENE, JJM ;

VANSAENE, HKF ;

GEITZ, JN ;

TARKOSMIT, NJP ;

LERK, CF .

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1986, 8 (01) :67-71

[17]

ZEITORN P, 1988, Patent No. 3046559

[18]

1990, 040540 SIM LAB WAVR

← 1 2 →