THE DETERMINATION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN PHARMACEUTICALS BY CAPILLARY ZONE ELECTROPHORESIS AND MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY

被引：88

作者：

DONATO, MG

BAEYENS, W

VANDENBOSSCHE, W

SANDRA, P

机构：

[1] STATE UNIV GHENT,FAC PHARMACEUT SCI,DEPT PHARMACEUT ANAL,HARELBEKEST 72,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT,INST ORGAN CHEM,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 01期

关键词：

NSAIDS; PHARMACEUTICAL FORMULATIONS; CAPILLARY ELECTROPHORESIS; MEKC;

D O I：

10.1016/0731-7085(94)80005-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ibuprofen, indomethacin, ketoprofen, piroxicam and diclofenac have been quantified in dragees, suspension, suppositories, capsules. injection solutions and tablets by capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (MEKC). The experiments were performed without specific sample pretreatment. The reproducibility of the method was investigated. Good quantitation was obtained in short analysis times. CE and MEKC are found to offer a good alternative to conventional HPLC methods.

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页码：21 / 26

页数：6

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