CONFORMATIONALLY RESTRICTED PEPTIDES THROUGH SHORT-RANGE CYCLIZATIONS

被引：276

作者：

TONIOLO, C

机构：

[1] Biopolymer Research Center, C.N.R, Department of Organic Chemistry, University of Padova, Padova

来源：

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1990年 / 35卷 / 04期

关键词：

cyclizations; cyclized peptides; peptide conformation; peptide surrogates; pseudopeptides; spectroscopy; X‐ray diffraction; β‐bends;

D O I：

10.1111/j.1399-3011.1990.tb00052.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The various types of conformationally restricted peptides obtained by short‐range cyclizations, from residue i to residue i+ 1, are presented. Relevant examples of N ⇆ Cx, C′⇆ Cx, N ⇆ C′, Cx⇆ Cx, C′⇆ C′ and N ⇆ N cyclizations are reported and the pertinent literature listed. In the discussion emphasis is place on the conformational consequences for peptides from the incorporation of such ring structures. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：287 / 300

页数：14

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