THE EVALUATION OF BIOEQUIVALENCE USING NONPARAMETRIC PROCEDURES

被引：8

作者：

CORNELL, RG

机构：

[1] Department of Biostatistics, University of Michigan, Ann Arbor, Michigan

来源：

COMMUNICATIONS IN STATISTICS-THEORY AND METHODS | 1990年 / 19卷 / 11期

关键词：

BIOEQUIVALENCE; NONPARAMETRIC;

D O I：

10.1080/03610929008830433

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

Applications of nonparametric methods to the evaluation of bioequivalence for two treatments are presented for independent samples and for a crossover design. Included are procedures for testing for equivalence in location, in dispersion, and in general. Also presented are procedures for the calculation of confidence limits. A general strategy for the evaluation of bioequivalence is developed which involves both hypothesis testing and the calculation of confidence limits for parameters which characterize departures from equivalence.

引用

页码：4153 / 4165

页数：13

共 22 条

[11] USE OF NON-PARAMETRIC METHODS IN STATISTICAL-ANALYSIS OF 2-PERIOD CHANGE-OVER DESIGN [J].