NEW GENE IN THE HOMOLOGOUS HUMAN 11Q13-Q14 AND MOUSE 7F CHROMOSOMAL REGIONS

被引：31

作者：

OLLENDORFF, V

SZEPETOWSKI, P

MATTEI, MG

GAUDRAY, P

BIRNBAUM, D

机构：

[1] INSERM,U119,MOLEC ONCOL LAB,27 BD LEI ROURE,F-13009 MARSEILLE,FRANCE

[2] UFR MED,LGMCH,CNRS,URA 1462,F-06034 NICE,FRANCE

[3] HOP LA TIMONE,INSERM,U242,F-13385 MARSEILLE,FRANCE

来源：

MAMMALIAN GENOME | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1007/BF00302877

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies in which most of the key genes remain to be identified. In an effort to isolate as many candidates as possible, we are cloning genes from this region. We report here the mapping of a new sequence from 11q13.5-11q14. This sequence, designated D11S833E, putatively encodes a new gene, provisionally named GARP. We cloned its homologous sequence in the mouse and located it on Chromosome (Chr) 7, region F. The human and mouse genes belong to a conserved group of synteny. This, together with the similar conservation of the FGF and TYR genes, indicates that the human 11q13-q14 and mouse 7E-7F regions share homology.

引用

页码：195 / 200

页数：6

共 40 条

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