AML WITH UNUSUAL CHROMOSOMAL CHANGES - TRANSLOCATION (15-21) AND 5Q- IN THE PRESENCE OF 2 NORMAL CHROMOSOMES-5

被引：2

作者：

CARRASCO, JL

JUAN, A

GOMEZ, AO

MIRANDA, JLG

BARROSO, MLB

GARCIA, MTH

NIETO, LH

机构：

[1] UNIV LA LAGUNA,FAC MED,CYTOGENET SERV,LA LAGUNA,SPAIN

[2] CANARY UNIV HOSP,HEMATOL SERV,CANARY ISL,SPAIN

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90076-K

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed serial cytogenetic studies of the bone marrow (BM) of a patient with acute myeloblastic leukemia (AML) and noted abnormal karyotypes 47,XY, + del(5)(q12q34),t(15;21)(q21;q22)/47,XY, + del(5)(q12q34) during the second relapse. Although a case of this t(15;21) was recently observed in a female patient with acute nonlymphocytic leukemia (ANLL) of subtype M4 of the French-American-British (FAB) classification, the present article constitutes the first report of its occurrence in association with ANLL of subtype M1-M2. Furthermore, the presence of the 5q - accompanied by two chromosomes 5 of normal appearance is very rare and of great interest.

引用

页码：139 / 141

页数：3

共 11 条

[1]

BENEDICT WF, 1979, BLOOD, V54, P818

[2] PROPOSED REVISED CRITERIA FOR THE CLASSIFICATION OF ACUTE MYELOID-LEUKEMIA - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].