METABOLISM OF 1,25(OH)2 16-ENE-D3 IN KIDNEY - INFLUENCE OF STRUCTURAL MODIFICATION OF D-RING ON SIDE-CHAIN METABOLISM

被引：22

作者：

REDDY, GS

CLARK, JW

TSERNG, KY

USKOKOVIC, MR

MCLANE, JA

机构：

[1] BROWN UNIV, ROGER WILLIAMS MED CTR, SCH MED, DEPT MED, PROVIDENCE, RI 02905 USA

[2] VET ADM MED CTR, MED RES SERV, CLEVELAND, OH 44106 USA

[3] CASE WESTERN RESERVE UNIV, DEPT NUTR & MED, CLEVELAND, OH 44106 USA

[4] HOFFMANN LA ROCHE INC, NUTLEY, NJ 07110 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80124-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Comparative metabolism studies between 1,25(OH)2D3 and 1,25(OH)2-16-ene D3 in rat kidney indicate that both compounds are metabolized into their respective 24 hydroxy and 24-oxo metabolites. While 1,25(OH)2-24-oxo-D3 is further metabolized into 1,23,25(OH)3-24-oxo-D3 in the usual fashion, 1,25(OH)2-24-oxo-16-ene D3 resists C-23 hydroxylation. Thus a minor change in D-ring structure appears to cause major changes in the side chain metabolism.

引用

页码：1879 / 1884

页数：6

共 12 条

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