A CONVENIENT METHOD FOR REGIOSELECTIVE C-5 HALOGENATION OF 4(3H)-OXO-7H-PYRROLO[2,3-D]PYRIMIDINES

被引：10

作者：

BARNETT, CJ

KOBIERSKI, ME

机构：

[1] Chemical Process Research and Development Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 05期

关键词：

D O I：

10.1002/jhet.5570310514

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-7, O-Disilylation of 4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidines provides a convenient method for activation of these compounds toward regiospecific halogenation at C-5. The sequence is conveniently carried out without isolation of the silylated derivatives and desilylation is spontaneous upon addition of water to the reaction mixture.

引用

页码：1181 / 1183

页数：3

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