IMMUNOPATHOGENESIS OF ORAL LICHEN-PLANUS

被引:131
作者
WALSH, LJ [1 ]
SAVAGE, NW [1 ]
ISHII, T [1 ]
SEYMOUR, GJ [1 ]
机构
[1] UNIV PENN, DEPT DERMATOL, PHILADELPHIA, PA 19104 USA
关键词
adhesion molecules; lichen planus; immunology; pathology; lymphocytes; mast cells;
D O I
10.1111/j.1600-0714.1990.tb00866.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Oral lichen planus (LP) is a common mucosal disorder in which cell mediated immunity is thought to play a major role. In this paper, a unifying hypothesis which attempts to integrate cellular and molecular signals in the local immune response in oral LP is presented. In this model, modified keratinocyte surface antigens are the target for the cytotoxic cell response which characterizes oral LP, whereas mast cells and antigen presenting Langerhans cells are key cellular elements in the evolving lesion. It has been established that mast cell degranulation induces adhesion molecule expression on endothelium which facilitates lymphocyte homing to the tissues. These adhesive interactions between lymphocytes and keratinocytes are postulated to be important determinants in the effector phase of the lesion. Cytokines produced by both lymphocytes and keratinocytes which influence the local immune response could promote chronicity. Accordingly, modulation of immunologic events is a potential therapeutic approach for oral LP. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:389 / 396
页数:8
相关论文
共 87 条
[31]  
JUNGELL P, 1989, SCAND J DENT RES, V97, P361
[32]  
KALISH RS, 1989, J IMMUNOL, V142, P74
[33]   LICHEN PLANUS EVOKED BY PERIODONTAL SURGERY [J].
KATZ, J ;
GOULTSCHIN, J ;
BENOLIEL, R ;
ROTSTEIN, I ;
PISANTY, S .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1988, 15 (04) :263-265
[34]  
KILPI AM, 1987, SCAND J DENT RES, V95, P174
[35]   HUMAN TONSILLAR DENDRITIC CELL-INDUCED T-CELL RESPONSES - ANALYSIS OF MOLECULAR MECHANISMS USING MONOCLONAL-ANTIBODIES [J].
KING, PD ;
KATZ, DR .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (04) :581-587
[36]   DE-GRANULATION OF HUMAN MAST-CELLS INDUCES AN ENDOTHELIAL ANTIGEN CENTRAL TO LEUKOCYTE ADHESION [J].
KLEIN, LM ;
LAVKER, RM ;
MATIS, WL ;
MURPHY, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8972-8976
[37]  
KONTTINEN YT, 1989, J CLIN LAB IMMUNOL, V28, P33
[38]  
KOWALSKI ML, 1988, J IMMUNOL, V140, P3905
[39]  
Kupper T S, 1988, Adv Dermatol, V3, P293