RECENT ADVANCES IN THE BORON ROUTE TO ASYMMETRIC-SYNTHESIS

被引：52

作者：

BROWN, HC

RAMACHANDRAN, PV

机构：

[1] H. C. Brown and R. B. Wetherill Laboratories of Chemistry, Purdue University, West Lafayette

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1351/pac199466020201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral organoboranes, readily available via asymmetric hydroboration or the Matteson asymmetric homologation reaction, have been successfully utilized for a general asymmetric synthesis of pure enantiomers. The recent continued successes achieved in our three-pronged approach to asymmetric synthesis - (1) asymmetric hydroboration, (2) asymmetric reduction, and (3) asymmetric allyl- and crotylboration, coupled with developments in asymmetric homologation, reveal the broad scope of these methodologies for the synthesis of stereoisomers in purities approaching 100 % ee.

引用

页码：201 / 212

页数：12

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