FURTHER NOVEL METABOLITES OF THE PARAHERQUAMIDE FAMILY

被引:77
作者
BLANCHFLOWER, SE
BANKS, RM
EVERETT, JR
READING, C
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,CHEMOTHERAPEUT RES CTR,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
[2] SMITHKLINE BEECHAM ANIM HLTH,TADWORTH KT20 7NT,SURREY,ENGLAND
关键词
D O I
10.7164/antibiotics.46.1355
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Four novel metabolites of a Penicillium strain, IMI 332995, which has previously been reported to produce paraherquamide and a number of related metabolites, are herein described. VM55596 is the first N-oxide to be found in this family of compounds. Unusual oxidative substitution is also seen in VM55597. VM55599 appears to be the first documented example of the hexacyclic indole species that have long been postulated as biosynthetic precursors of metabolites of the brevianamide, paraherquamide and marcfortine families.
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页码:1355 / 1363
页数:9
相关论文
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  • [11] ASYMMETRIC, STEREOCONTROLLED TOTAL SYNTHESIS OF (-)-BREVIANAMIDE-B
    WILLIAMS, RM
    GLINKA, T
    KWAST, E
    COFFMAN, H
    STILLE, JK
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (02) : 808 - 821