TRANSPLACENTAL TRANSPORT IN THE RABBIT OF VITAMIN-B12 BOUND TO HUMAN TRANSCOBALAMIN-I, TRANSCOBALAMIN-II AND TRANSCOBALAMIN-III

被引：15

作者：

FERNANDESCOSTA, F ^{[1
]}

METZ, J ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,JOHANNESBURG 2001,SOUTH AFRICA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03795.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary. Transcobalamins I, II and III (TCI, TCII, TCIII) were purified from human serum, saturated with 57Co‐vitamin B12 (57Co‐B12), and injected into pregnant rabbits. Whole body retention of the 57Co‐B12 averaged 91% and was similar for each of the three vitamin B12 binders. A maximum of 62% of the injected 57Co‐B12 was found in fetal tissues when the vitamin was injected bound to TCII, but only 6–7% when bound to TCI or TCIII. Thus TCII is responsible for the delivery of vitamin B12 to the fetus. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：625 / 630

页数：6

共 27 条

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