TRANSPLACENTAL TRANSPORT IN THE RABBIT OF VITAMIN-B12 BOUND TO HUMAN TRANSCOBALAMIN-I, TRANSCOBALAMIN-II AND TRANSCOBALAMIN-III

被引：15

作者：

FERNANDESCOSTA, F ^{[1
]}

METZ, J ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,JOHANNESBURG 2001,SOUTH AFRICA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03795.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary. Transcobalamins I, II and III (TCI, TCII, TCIII) were purified from human serum, saturated with 57Co‐vitamin B12 (57Co‐B12), and injected into pregnant rabbits. Whole body retention of the 57Co‐B12 averaged 91% and was similar for each of the three vitamin B12 binders. A maximum of 62% of the injected 57Co‐B12 was found in fetal tissues when the vitamin was injected bound to TCII, but only 6–7% when bound to TCI or TCIII. Thus TCII is responsible for the delivery of vitamin B12 to the fetus. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：625 / 630

页数：6

共 27 条

[11] GAMS RA, 1976, BLOOD, V47, P923
[12] GIZIS EJ, 1970, J LAB CLIN MED, V75, P673
[13] RAPID CHARCOAL ASSAY FOR INTRINSIC FACTOR (IF) GASTRIC JUICE UNSATURATED B12 BINDING CAPACITY ANTIBODY TO IF AND SERUM UNSATURATED B12 BINDING CAPACITY
GOTTLIEB, C
LAU, KS
WASSERMA.LR
HERBERT, V
[J]. BLOOD-THE JOURNAL OF HEMATOLOGY, 1965, 25 (06): : 875 - &
[14] PLACENTAL TRANSPORT OF VITAMIN-B12 IN PREGNANT RAT
GRABER, SE
SCHEFFEL, U
HODKINSON, B
MCINTYRE, PA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (05) : 1000 - +
[15] MOUSE TRANSCOBALAMIN - 110 BIOSYNTHESIS AND UPTAKE BY L-929 CELLS
GREEN, PD
SAVAGE, CR
HALL, CA
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 176 (02) : 683 - 689
[16] HALL CA, 1977, AM J HUM GENET, V29, P619
[17] UPTAKE OF VITAMIN-B12 BY PHYTOHAEMAGGLUTININ-TRANSFORMED LYMPHOCYTES
HOFFBRAND, AV
TRIPP, E
DAS, KC
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1973, 24 (02) : 147 - 156
[18] JACOB E, 1975, J LAB CLIN MED, V86, P505
[19] NEXO E, 1978, CLIN RES, V26, pA620
[20] OSTROY F, 1977, BLOOD, V50, P877

← 1 2 3 →