AN EFFICIENT CHEMOENZYMIC ACCESS TO OPTICALLY-ACTIVE MYOINOSITOL POLYPHOSPHATES

被引：34

作者：

GOU, DM ^{[1
]}

LIU, YC ^{[1
]}

CHEN, CS ^{[1
]}

机构：

[1] UNIV RHODE ISL, COLL PHARM, DEPT PHARMACOGNOSY & ENVIRONM HLTH SCI, KINGSTON, RI 02881 USA

来源：

CARBOHYDRATE RESEARCH | 1992年 / 234卷

关键词：

D O I：

10.1016/0008-6215(92)85038-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1,4.5-tris-, 1,3,4-tris-, and 1,3,4,5-tetrakis-phosphates of 1D-myo-inositol have been prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5.6-di-O-cyclohexylidene-myo-inositol. A facile enzymic preparation is also described of these chiral intermediates through enantiospecific deacylation of the corresponding racemic esters.

引用

页码：51 / 64

页数：14

共 24 条

[1] A SYNTHESIS OF 1D-MYO-INSITOL AND 1L-MYO-INOSITOL 1,3,4,5-TETRAPHOSPHATE [J].

BAUDIN, G ;

GLANZER, BI ;

SWAMINATHAN, KS ;

VASELLA, A .

HELVETICA CHIMICA ACTA, 1988, 71 (05) :1367-1378

[2] INOSITOL PHOSPHATES AND CELL SIGNALING [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1989, 341 (6239) :197-205

[3]

BERRIDGE MJ, 1989, INOSITOL LIPIDS CELL

[4] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].

CHEN, CS ;

FUJIMOTO, Y ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7294-7299

[5]

DESAI T, 1991, ACS SYM SER, V463, P86

[6]

DREEF CE, 1988, RECL TRAV CHIM PAY B, V107, P395

[7] ENANTIOSPECIFIC SYNTHESIS OF D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE FROM (-)-QUINIC ACID [J].

FALCK, JR ;

YADAGIRI, P .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (25) :5851-5852

[8] SYNTHESIS OF SOME MONO-O-BENZYL-MYO-INOSITOL AND PENTA-O-METHYL-MYO-INOSITOL [J].

GAREGG, PJ ;

IVERSEN, T ;

JOHANSSON, R ;

LINDBERG, B .

CARBOHYDRATE RESEARCH, 1984, 130 (JUL) :322-326

[9] AN EFFICIENT ROUTE TO D-MYO-INOSITOL 1,3,4-TRIPHOSPHATE AND D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE [J].

GOU, DM ;

CHEN, CS .

TETRAHEDRON LETTERS, 1992, 33 (06) :721-724

[10] SEQUENTIAL BIOCATALYTIC KINETIC RESOLUTIONS [J].

GUO, ZW ;

WU, SH ;

CHEN, CS ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) :4942-4945

← 1 2 3 →