Genetics of IgA deficiency

被引：19

作者：

Truedsson, L ^{[1
]}

Baskin, B ^{[1
]}

Pan, Q ^{[1
]}

Rabbani, H ^{[1
]}

Vorechovsky, I ^{[1
]}

Smith, CIE ^{[1
]}

Hammarstrom, L ^{[1
]}

机构：

[1] LUND UNIV,DEPT MED MICROBIOL,CLIN IMMUNOL SECT,LUND,SWEDEN

来源：

APMIS | 1995年 / 103卷 / 12期

关键词：

IgA deficiency; common variable immunodeficiency; immune regulation; immunoglobulin switch; genetics;

D O I：

10.1111/j.1699-0463.1995.tb01442.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgA deficiency is the most common humoral defect in man and results in an increased susceptibility to respiratory tract and gastrointestinal infections. Both clinical and genetic data support a close relationship with common variable immunodeficiency, a disease which involves not only IgA and IgG production, but also, in half of the patients, IgM. It is likely that the two disorders represent an allelic condition with a variable expression of a common gene defect which is thought to be involved in the regulation of immunoglobulin class switching. It is possible that a single, autosomally inherited gene with a limited penetrance is responsible for the development of both these defects.

引用

页码：833 / 842

页数：10