GENOMIC ORGANIZATION OF THE TRANSPOSABLE ELEMENT TDD-3 FROM DICTYOSTELIUM-DISCOIDEUM

被引：11

作者：

MARSCHALEK, R ^{[1
]}

BORSCHET, G ^{[1
]}

DINGERMANN, T ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,FAK MED,INST BIOCHEM,FAHRSTR 17,W-8520 ERLANGEN,GERMANY

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 19期

关键词：

D O I：

10.1093/nar/18.19.5751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transposable element Tdd-3 from D. discoideum has been described originally In 1984 (Poole and Firtel, 1984). Additional copies of this element were discovered in the course of a recent study on tRNA gene organization in D. discoideum. Five out of 24 independently isolated tRNA genes proved to be associated with Tdd-3 elements. The surprising observation that all the elements always occurred within the 3′-flanking sequences of the Dictyostelium tRNA genes suggested the possibility of a general position specific integration of Tdd-3 elements upon transposition. Therefore we isolated additional Tdd-3 elements from various genomic D. discoideum libraries in order to test this hypothesis. Several new Tdd-3 elements were found associated with various tRNA genes. Additionally we identified Tdd-3 elements organized In tandem array or In association with RED (Repetitive Element of Dictyostelium), another repetitive element recently identified by our laboratory. In all cases a B-box equivalent of the eukaryotic gene-internal RNA polymerase III promoter was identified upstream of all Tdd-3 elements. © 1990 Oxford University Press.

引用

页码：5751 / 5757

页数：7

共 20 条

[11] TRANSFER-RNA GENES - LANDMARKS FOR INTEGRATION OF MOBILE GENETIC ELEMENTS IN DICTYOSTELIUM-DISCOIDEUM [J].

MARSCHALEK, R ;

BRECHNER, T ;

AMONBOHM, E ;

DINGERMANN, T .

SCIENCE, 1989, 244 (4911) :1493-1496

[12] GENOMIC INSTABILITY AND MOBILE GENETIC ELEMENTS IN REGIONS SURROUNDING 2 DISCOIDIN-I GENES OF DICTYOSTELIUM-DISCOIDEUM [J].

POOLE, SJ ;

FIRTEL, RA .

MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (04) :671-680

[13] SIGMA-ELEMENTS ARE POSITION-SPECIFIC FOR MANY DIFFERENT YEAST TRANSFER-RNA GENES [J].

SANDMEYER, SB ;

BILANCHONE, VW ;

CLARK, DJ ;

MORCOS, P ;

CARLE, GF ;

BRODEUR, GM .

NUCLEIC ACIDS RESEARCH, 1988, 16 (04) :1499-1515

[14] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[15] STRUCTURE AND TRANSCRIPTION OF EUKARYOTIC TRANSFER-RNA GENES [J].

SHARP, SJ ;

SCHAACK, J ;

COOLEY, L ;

BURKE, DJ ;

SOLL, D .

CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1985, 19 (02) :107-144

[16] GROWTH OF MYXAMOEBAE OF CELLULAR SLIME MOULD DICTYOSTELIUM-DISCOIDEUM IN AXENIC CULTURE [J].

WATTS, DJ ;

ASHWORTH, JM .

BIOCHEMICAL JOURNAL, 1970, 119 (02) :171-&

[17] NONVIRAL RETROPOSONS - GENES, PSEUDOGENES, AND TRANSPOSABLE ELEMENTS GENERATED BY THE REVERSE FLOW OF GENETIC INFORMATION [J].

WEINER, AM ;

DEININGER, PL ;

EFSTRATIADIS, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :631-661

[18]

WELKER DL, 1982, GENETICS, V109, P691

[19] THE SITE-SPECIFIC RIBOSOMAL DNA INSERTION ELEMENT R1BM BELONGS TO A CLASS OF NON-LONG-TERMINAL-REPEAT RETROTRANSPOSONS [J].

XIONG, Y ;

EICKBUSH, TH .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (01) :114-123

[20] FUNCTIONAL EXPRESSION OF A SEQUENCE-SPECIFIC ENDONUCLEASE ENCODED BY THE RETROTRANSPOSON R2BM [J].

XIONG, Y ;

EICKBUSH, TH .

CELL, 1988, 55 (02) :235-246

← 1 2 →