SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2'-DEOXY-4'-THIOPYRIMIDINE NUCLEOSIDES

被引：186

作者：

SECRIST, JA

TIWARI, KN

RIORDAN, JM

MONTGOMERY, JA

机构：

[1] Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 08期

关键词：

D O I：

10.1021/jm00112a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2'-Deoxy-4'-thiocytidine (7-beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.

引用

页码：2361 / 2366

页数：6

共 23 条

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