9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)GUANINE - A METABOLICALLY STABLE CYTOTOXIC ANALOG OF 2'-DEOXYGUANOSINE

被引:50
作者
MONTGOMERY, JA [1 ]
SHORTNACY, AT [1 ]
CARSON, DA [1 ]
SECRIST, JA [1 ]
机构
[1] SCRIPPS CLIN & RES FDN, DEPT CLIN RES, LA JOLLA, CA 92037 USA
关键词
D O I
10.1021/jm00161a041
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2389 / 2392
页数:4
相关论文
共 27 条
  • [1] BEAMAN AG, 1963, J ORG CHEM, V28, P2310
  • [2] BENNETT LL, 1976, MOL PHARMACOL, V12, P242
  • [3] BIOCHEMICAL BASIS FOR THE ENHANCED TOXICITY OF DEOXYRIBONUCLEOSIDES TOWARD MALIGNANT HUMAN T-CELL LINES
    CARSON, DA
    KAYE, J
    MATSUMOTO, S
    SEEGMILLER, JE
    THOMPSON, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (05) : 2430 - 2433
  • [4] LYMPHO-SPECIFIC TOXICITY IN ADENOSINE-DEAMINASE DEFICIENCY AND PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY - POSSIBLE ROLE OF NUCLEOSIDE KINASE(S)
    CARSON, DA
    KAYE, J
    SEEGMILLER, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5677 - 5681
  • [5] DEOXYADENOSINE TRIPHOSPHATE AS A POTENTIALLY TOXIC METABOLITE IN ADENOSINE-DEAMINASE DEFICIENCY
    COHEN, A
    HIRSCHHORN, R
    HOROWITZ, SD
    RUBINSTEIN, A
    POLMAR, SH
    HONG, R
    MARTIN, DW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) : 472 - 476
  • [6] COHEN A, 1983, BLOOD, V61, P660
  • [7] DEOXYGUANOSINE TRIPHOSPHATE AS A POSSIBLE TOXIC METABOLITE IN IMMUNODEFICIENCY ASSOCIATED WITH PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY
    COHEN, A
    GUDAS, LJ
    AMMANN, AJ
    STAAL, GEJ
    MARTIN, DW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (05) : 1405 - 1409
  • [8] COLEMAN MS, 1978, J BIOL CHEM, V253, P1619
  • [9] BIOLOGICAL-ACTIVITIES OF SOME PURINE ARABINOSIDES
    ELION, GB
    RIDEOUT, JL
    DEMIRANDA, P
    COLLINS, P
    BAUER, DJ
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 255 (AUG8) : 468 - 480
  • [10] FRIDLAND A, 1985, P SOC EXP BIOL MED, V179, P456