INDUCTION OF NF-CHI-B DURING MONOCYTE DIFFERENTIATION IS ASSOCIATED WITH ACTIVATION OF HIV-GENE EXPRESSION

被引:50
作者
GRIFFIN, GE
LEUNG, K
FOLKS, TM
KUNKEL, S
NABEL, GJ
机构
[1] UNIV MICHIGAN,MED CTR,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109
[2] CTR DIS CONTROL,RETROVIRUS DIS BRANCH,ATLANTA,GA 30333
[3] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109
来源
RESEARCH IN VIROLOGY | 1991年 / 142卷 / 2-3期
基金
英国惠康基金;
关键词
HIV; MONOCYTE; MACROPHAGE; AIDS; NF-CHI-B; PHORBOL ESTER; TNF-ALPHA; CELL MATURATION; TRANSCRIPTION;
D O I
10.1016/0923-2516(91)90062-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Cells of the monocyte-macrophage lineage are important targets of HIV infection. We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF-alpha) is associated with expression of nuclear factor kappa B (NF-chi-B). In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene construct, is activated in such cells under the influence of enhanced NF-chi-B expression. Also, in a promonocyte cell line chronically infected with HIV, NF-chi-B expression and HIV transcription were enhanced on stimulation with phorbol ester or TNF-alpha. Thus, stimulation of monocyte cell lines by phorbol esters or TNF-alpha induces cell differentiation and activates HIV transcription. Such a process may have fundamental implications in AIDS pathogenesis in vivo and may be important in disease progression induced by opportunistic infections directly or indirectly involving macrophages.
引用
收藏
页码:233 / 238
页数:6
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