BIOMIMETIC OXIDATION OF 21-HYDROXY, 21-FORMYL AND 21-CARBOXYLIC PREGN-4-EN-3,20-DIONE WITH CHEMICAL CYTOCHROME-P450 MODEL SYSTEMS

被引：11

作者：

CHAUHAN, SMS

RAY, PC

机构：

[1] Department of Chemistry, University of Delhi, Delhi

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)81160-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The electron withdrawing 5,10,15,20-tetra(2',6'-dichlorophenyl)porphyrin iron (III)chloride [Cl8TPPFe(III)Cl] and 5,10,15,20-tetra(2',3',4',5',6'-pentafluorophenyl)porphyrin iron (III)chloride [F20TPPFe(III)Cl] are more efficient catalysts than sterically hindered 5,10,15,20-tetra(2',4',6'-trimethylphenyl)porphyrin iron(III)chloride during the biomimetic oxidation of 21-hydroxypregn-4-en-3,20-dione with CumOOH in the presence of N-methylimidazole.

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页码：601 / +

页数：1

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