EFFECTS OF UGILEC-141, A PCB SUBSTITUTE BASED ON TETRACHLOROBENZYLTOLUENES, ON HEPATIC MONO-OXYGENASE INDUCTION IN ESTUARINE FISH

被引：16

作者：

ADDISON, RF ^{[1
]}

HANSEN, PD ^{[1
]}

PLUTA, HJ ^{[1
]}

WILLIS, DE ^{[1
]}

机构：

[1] FED HLTH OFF,INST WATER SOIL & AIR HYG,W-1000 BERLIN 33,GERMANY

来源：

MARINE ENVIRONMENTAL RESEARCH | 1991年 / 31卷 / 02期

关键词：

D O I：

10.1016/0141-1136(91)90024-3

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Ugilec-141(R) is a PCB substitute based on chlorinated benzyltoluenes which has been reported as an environmental contaminant in some German rivers. It is structurally similar to some phenylxylylethanes which induce hepatic microsomal mono-oxygenases in fish. When injected i.p. into dab (Limanda limanda) or flounder (Platichthys flesus) Ugilec-141 did not consistently induce hepatic microsomal ethoxyresorufin O-de-ethylase (EROD), ethoxycoumarin O-de-ethylase (ECOD) or pentoxyresorufin O-de-alkylase (PROD). When injected into winter flounder (Pseudopleuronectes americanus) to yield tissue concentrations in the 2-40-mu-g/g range, Ugilec-141 slightly (but significantly) induced EROD (2.4-fold), ECOD (2.5-fold) and 3-cyano-7-ethoxycoumarin O-de-ethylase (4.4-fold). The classic inducer, beta-naphthoflavone, consistently induced all these indices of mono-oxygenase activity in all species. Components of Ugilec-141 therefore appear to be only mild inducers of fish hepatic microsomal mono-oxygenase systems.

引用

页码：137 / 144

页数：8

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