RELOCALIZATION OF ACTSK-1 TO MOUSE CHROMOSOME-8, A NEW REGION OF HOMOLOGY WITH HUMAN CHROMOSOME-1

被引：9

作者：

ALONSO, S ^{[1
]}

MONTAGUTELLI, X ^{[1
]}

SIMONCHAZOTTES, D ^{[1
]}

GUENET, JL ^{[1
]}

BUCKINGHAM, M ^{[1
]}

机构：

[1] INST PASTEUR,UNITE GENET MAMMIFERES,URA 361,F-75724 PARIS 15,FRANCE

来源：

MAMMALIAN GENOME | 1993年 / 4卷 / 01期

关键词：

D O I：

10.1007/BF00364657

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present here the genetic mapping of the alpha-skeletal actin locus (Actsk-1) on mouse Chromosome (Chr) 8, on the basis of the PCR analysis of a microsatellite in an interspecific backcross. Linkage and genetic distances were established for four loci by analysis of 192 (or 222) melotic events and indicated the following gene order: (centromere)-Es-1-11.7 cM-Tat-8.3 cM-Actsk-1-0.5 cM-Aprt. Mapping of ACTSK to human Chr 1 and of TAT and APRT to human Chr 16 demonstrates the existence of a new short region of homology between mouse Chr 8 and human Chr 1. Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies.

引用

页码：15 / 20

页数：6

共 33 条

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