HIV PROTEASE LIGAND COMPLEXES

HIV-1 protease remains a promising target for the treatment of AIDS, and research continues in many laboratories to exploit a knowledge of the structure of the protease and its interactions with inhibitors in the development of an AIDS therapy. Structures of HIV-1 protease in complex with peptide-based inhibitors continue to be reported, and recently structures have appeared for a number of compounds that are not fundamentally peptidyl in nature, compounds that were identified as inhibitors either by screening methods or by structure-based database searches. Three structures of the closely related HIV-2 protease in complex with peptide-based inhibitors have now also been determined.