IDENTIFICATION AND CHARACTERIZATION OF NORMAL LENGTH NONFLUORESCENT Y-CHROMOSOMES - CYTOGENETIC ANALYSIS, SOUTHERN HYBRIDIZATION AND NONISOTOPIC INSITU HYBRIDIZATION

被引：23

作者：

SPELEMAN, F

VANDERAUWERA, B

MANGELSCHOTS, K

VERCRUYSSEN, M

RAAP, T

WIEGANT, J

CRAEN, M

LEROY, J

机构：

[1] LEIDEN STATE UNIV,DEPT CYTOCHEM & CYTOMETRY,2333 AL LEIDEN,NETHERLANDS

[2] STATE UNIV GHENT HOSP,DEPT PEDIAT,B-9000 GHENT,BELGIUM

[3] UNIV INSTELLING ANTWERP,DEPT MED GENET,B-2610 WILRIJK,BELGIUM

来源：

HUMAN GENETICS | 1990年 / 85卷 / 06期

关键词：

D O I：

10.1007/BF00193576

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In two female patients with a 45,X/46,X,+mar karyotype the marker chromosomes were identified as normal length nonfluorescent Y chromosomes (nlYnf) using non-isotopic in situ hybridization (NISH) complementary to routine cytogenetic analysis and Southern hybridization. The recognition of the nlYnf as isodicentric in both patients illustrates and confirms the usefulness and importance of NISH in the identification and characterization of this and many other types of complex chromosome rearrangements. © 1990 Springer-Verlag.

引用

页码：569 / 575

页数：7

共 50 条

[31] MAPPING THE HUMAN ZFX LOCUS TO XP21.3 BY INSITU HYBRIDIZATION [J].