SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 9-MERCAPTODETHIOBIOTIN - A PUTATIVE BIOTIN PRECURSOR IN ESCHERICHIA-COLI

被引：24

作者：

BAXTER, RL ^{[1
]}

CAMP, DJ ^{[1
]}

COUTTS, A ^{[1
]}

SHAW, N ^{[1
]}

机构：

[1] LONZA AG,CH-3930 VISP,SWITZERLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 02期

关键词：

D O I：

10.1039/p19920000255

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of (+/-)-9-mercaptodethiobiotin 3 via the aldehyde 9 is described. Compound (+/-)-3 does not function as a biotin replacement factor for an E. coli mutant (SA291) lacking the entire biotin synthesis operon (bioABFCD-) but supports growth of an E. coli bioA mutant. Compound (+/-)-3 also supports growth of transformed cells of SA291 carrying a plasmid encoding the E. coli biotin synthase (bioB) gene indicating that the compound may be able to substitute for dethiobiotin 2 as a substrate for biotin synthase.

引用

页码：255 / 258

页数：4

共 18 条

[1]

ARIGONI D, COMMUNICATION

[2] DELETION AND COMPLEMENTATION ANALYSIS OF BIOTIN GENE CLUSTER OF ESCHERICHIA-COLI [J].