ADIPOSE HORMONE-SENSITIVE LIPASE PREFERENTIALLY RELEASES POLYUNSATURATED FATTY-ACIDS FROM TRIGLYCERIDES

被引:67
作者
GAVINO, VC
GAVINO, GR
机构
[1] Department of Nutrition, Université de Montréal, Montréal, H3C 3J7, Québec, Station A
关键词
D O I
10.1007/BF02535570
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rat adipose hormone-sensitive lipase-mediated release of fatty acids from triglycerides was studied in three model systems: i) cultured preadipocytes containing polyunsaturated fatty acid-enriched triglyceride; ii) perfused epididymal fat pads; and iii) in vitro incubations of crude preparations of hormone-sensitive lipase with synthetic triglyceride-analogues as substrates. We found that cultured preadipocytes challenged with 10 muM norepinephrine tended to release more omega6 and omega3 polyunsaturated fatty acids than saturated fatty acids. Fat pads perfused with 10 muM norepinephrine preferentially released arachidonate and alpha-linolenate but tended to retain oleate and linoleate. Finally, crude preparations of hormone-sensitive lipase released from the triglyceride-analogue substrates alpha-linolenate twice as fast as oleate. We conclude that rat adipose hormone-sensitive lipase preferentially releases polyunsaturated fatty acids from triglycerides. We suggest that this may be a mechanism by which these fatty acids are kept from being trapped in fat depots and maintained in the circulation.
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页码:950 / 954
页数:5
相关论文
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