BINDING-STUDIES WITH RECOMBINANT HUMAN SERUM-ALBUMIN OBTAINED BY EXPRESSION OF A SYNTHETIC GENE IN YEAST - STEREOSELECTIVE BINDING AND ALLOSTERIC INTERACTION WITH BENZODIAZEPINE AND COUMARIN LIGANDS

被引：6

作者：

FITOS, I ^{[1
]}

VISY, J ^{[1
]}

SIMONCSITS, A ^{[1
]}

机构：

[1] UNIV STOCKHOLM,DEPT NEUROCHEM & NEUROTOXICOL,S-10691 STOCKHOLM,SWEDEN

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 07期

关键词：

D O I：

10.1016/0006-2952(93)90464-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The specific ligand binding ability of recombinant human serum albumin produced in yeast using the synthetic gene was studied by affinity chromatographic method. It was found that synthetic protein possesses those stereoselective binding and binding interactions for several chiral benzodiazepine and coumarin compounds which are characteristic of the natural human serum albumin, suggesting identical tertiary structures.

引用

页码：1159 / 1163

页数：5

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