IMMUNOHISTOCHEMICAL LOCALIZATION OF MINERALOCORTICOID RECEPTOR IN HUMAN GUT

被引：12

作者：

FUKUSHIMA, K

SASANO, H

NAGURA, H

SASAKI, I

MATSUNO, S

KROZOWSKI, ZS

机构：

[1] TOHOKU UNIV, SCH MED, DEPT PATHOL, SENDAI, MIYAGI 980, JAPAN

[2] BAKER MED RES INST, PRAHRAN, VIC 3181, AUSTRALIA

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 165卷 / 02期

关键词：

MINERALOCORTICOID RECEPTOR; IMMUNOHISTOCHEMISTRY; HUMAN GUT;

D O I：

10.1620/tjem.165.155

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunohistochemical localization of mineralocorticoid receptor in the human adult gut was examined by using a polyclonal antibody raised against a mineralocorticoid receptor fusion protein. Immunoreactive staining was observed in columnar cells in the middle of the intestinal glands of the proximal colon, but not in goblet cells. Western blot analysis also revealed the presence of an approximately 100 kDa immunoreactive species consistent with the mineralocorticoid receptor protein in the ascending colon as well as the kidney. These results suggest that aldosterone-sensitive sodium transport and water absorption may be mainly carried out in the proximal colon in human adult gut at non-pathological state.

引用

页码：155 / 163

页数：9

共 26 条

[1]

ABRAMS JS, 1984, ABDOMINAL STOMAS, P1

[2] CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].