LOW-TEMPERATURE 2-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION SPECTROSCOPY OF A 1,4-BENZODIAZEPINE

被引：7

作者：

LAPLANCHE, LA ^{[1
]}

ROTHCHILD, R ^{[1
]}

机构：

[1] CUNY JOHN JAY COLL CRIMINAL JUSTICE,CTR TOXICOL RES & TRAINING,DEPT SCI,NEW YORK,NY 10019

来源：

SPECTROSCOPY LETTERS | 1991年 / 24卷 / 01期

关键词：

KETAZOLAM; C-13 NMR CHEMICAL SHIFTS; VARIABLE TEMPERATURE STUDIES; 2D LONG-RANGE C-13-H-1 SHIFT CORRELATION; HINDERED ROTATION; 1,4-BENZODIAZEPINES; LANTHANIDE-INDUCED SHIFTS; BENZODIAZEPINE DRUGS; NMR; C-13;

D O I：

10.1080/00387019108018127

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The unsubstituted phenyl ring in ketazolam, a 1,4-benzodiazepine derivative, has a two-fold rotational barrier about the aryl to tert-alkyl bond connecting this phenyl group to the rest of the molecule. At 50.3 MHz, all twenty of the C-13 resonances of ketazolam are resolved below -40-degrees-C, including two distinct resonances for the ortho carbons and two for the meta carbons. Twelve of the twenty C-13 nuclei resonate between 138 and 125 ppm, necessitating assignment via a combination of one-bond and long-range heteronuclear shift correlation experiments.

引用

页码：99 / 126

页数：28

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