AUTOIMMUNITY IN THE EYE AND ITS REGULATION

被引:54
作者
GERY, I
STREILEIN, JW
机构
[1] NEI, 10 CTR DR, BLDG 10, ROOM 10N208, BETHESDA, MD 20892 USA
[2] SCHEPENS EYE RES INST, BOSTON, MA 02114 USA
关键词
D O I
10.1016/0952-7915(94)90017-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent studies have provided new information concerning the development of autoimmune-mediated intraocular inflammation (uveitis) and the mechanisms that suppress this sight-robbing process. Newly collected data have led to several interesting advances: the discovery of additional uveitogenic antigens and novel uveitogenic reactions; dissection or the early steps of the pathogenic process; identification of the subsets of lymphocytes that selectively accumulate in the inflamed eye; analysis of the development of tolerance against sequestered antigens in the eye; elucidation of the cellular and molecular events of the anterior chamber-associated immune deviation, the major immunoregulatory mechanism in the eye; the capacity of this mechanism to inhibit and even treat uveitis; and examination of the mechanisms whereby oral tolerance inhibits ocular inflammation.
引用
收藏
页码:938 / 945
页数:8
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