CATECHOLAMINES AND DIABETIC AUTONOMIC NEUROPATHY

被引:17
作者
HILSTED, J [1 ]
机构
[1] HVIDOVRE UNIV HOSP,DEPT ENDOCRINOL,COPENHAGEN,DENMARK
关键词
DIABETES; AUTONOMIC NEUROPATHY; ADRENALINE NORADRENALINE; SECRETION RATE; CLEARANCE; ALPHA ADRENOCEPTORS; BETA ADRENOCEPTORS;
D O I
10.1111/j.1464-5491.1995.tb00479.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In diabetic patients with autonomic neuropathy plasma noradrenaline concentration, used as an index of sympathetic nervous activity, is low. This decrease is, however, only found in patients with a long duration of diabetes with clinically severe autonomic neuropathy. This apparent insensitivity of plasma catecholamine measurements is not due to changes in the clearance of catecholamines in diabetic autonomic neuropathy. The physiological responses to infused adrenaline and to noradrenaline are enhanced, for noradrenaline mainly cardiovascular responses. Adrenoceptors (alpha and beta adrenoceptors) are not altered in circulating blood cells in diabetic autonomic neuropathy. Thus, a generalized up-regulation of adrenoceptors does not occur in diabetic autonomic neuropathy.
引用
收藏
页码:296 / 297
页数:2
相关论文
共 12 条
[1]  
Engelman K., Portnoy B., A sensitive double isotope derivative assay for norepinephrine and epinephrine: normal resting human plasma levels, Circ Res, 26, pp. 53-57, (1970)
[2]  
Christensen NJ, Henriksen O., Lassen NA, The Sympathoadrenal System, pp. 1-512, (1986)
[3]  
Christensen NJ, Plasma catecholamines in long‐term diabetics with and without neuropathy and in hypophysectomized subjects, J Clin Invest, 51, pp. 779-787, (1972)
[4]  
Cryer PE, Disorders of sympathetic neural function in human diabetes mellitus: hyperadrenergic and hypoadrenergic postural hypotension, Metabolism, 29, pp. 186-189, (1980)
[5]  
Leveston SA, Shah SD, Cryer PE, Cholinergic stimulation of norepinephrine release in man. Evidence of a sympathetic postganglionic axonal lesion in diabetic adrenergic neuropathy, J Clin Invest, 64, pp. 370-380, (1979)
[6]  
Hilsted J., Parving H-H, Galbo H., Christensen NJ, Benn J., Hemodynamics in diabetic orthostatic hypotension, J Clin Invest, 68, pp. 1427-1434, (1981)
[7]  
Dejgaard A., Hilsted J., Henriksen JH., Christensen N.J, Plasma adrenaline kinetics in type 1 (insulin‐dependent) diabetic patients with and without autonomic neuropathy, Diabetologia, 32, pp. 810-813, (1989)
[8]  
Dejgaard A., Hilsted J., Christensen NJ, Noradrenaline and isoproterenol kinetics in diabetic patients with and without autonomic neuropathy, Diabetologia, 29, pp. 773-777, (1986)
[9]  
Dejgaard A., Liggett SB, Christensen NJ, Cryer PE, Adrenergic receptors are a fallible index of denervation hypersensitivity, Scand J Clin Lab Invest, 51, pp. 659-666, (1991)
[10]  
Wahrenberg H., Arner P., Adamsson U., Lins P-E, Juhlin-Dannfelt A., Ostman J., Increased lipolytic sensitivity to catecholamines in diabetic patients with severe autonomic neuropathy, J Int Med, 227, pp. 309-316, (1990)