CATECHOLAMINES AND DIABETIC AUTONOMIC NEUROPATHY

被引：17

作者：

HILSTED, J ^{[1
]}

机构：

[1] HVIDOVRE UNIV HOSP,DEPT ENDOCRINOL,COPENHAGEN,DENMARK

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 04期

关键词：

DIABETES; AUTONOMIC NEUROPATHY; ADRENALINE NORADRENALINE; SECRETION RATE; CLEARANCE; ALPHA ADRENOCEPTORS; BETA ADRENOCEPTORS;

D O I：

10.1111/j.1464-5491.1995.tb00479.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In diabetic patients with autonomic neuropathy plasma noradrenaline concentration, used as an index of sympathetic nervous activity, is low. This decrease is, however, only found in patients with a long duration of diabetes with clinically severe autonomic neuropathy. This apparent insensitivity of plasma catecholamine measurements is not due to changes in the clearance of catecholamines in diabetic autonomic neuropathy. The physiological responses to infused adrenaline and to noradrenaline are enhanced, for noradrenaline mainly cardiovascular responses. Adrenoceptors (alpha and beta adrenoceptors) are not altered in circulating blood cells in diabetic autonomic neuropathy. Thus, a generalized up-regulation of adrenoceptors does not occur in diabetic autonomic neuropathy.

引用

页码：296 / 297

页数：2