STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND

被引：1184

作者：

DESAUVAGE, FJ

HASS, PE

SPENCER, SD

MALLOY, BE

GURNEY, AL

SPENCER, SA

DARBONNE, WC

HENZEL, WJ

WONG, SC

KUANG, WJ

OLES, KJ

HULTGREN, B

SOLBERG, LA

GOEDDEL, DV

EATON, DL

机构：

[1] MAYO CLIN, DIV HEMATOL ONCOL, JACKSONVILLE, FL 32224 USA

[2] GENENTECH INC, DEPT MOLEC BIOL, San Francisco, CA 94080 USA

[3] GENENTECH INC, DEPT CARDIOVASC RES, San Francisco, CA 94080 USA

[4] GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA

[5] MAYO CLIN & MAYO FDN, DIV HEMATOL ONCOL, ROCHESTER, MN 55905 USA

来源：

NATURE | 1994年 / 369卷 / 6481期

关键词：

D O I：

10.1038/369533a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

引用

页码：533 / 538

页数：6

共 48 条

[11] HARRINGTON MG, 1990, METHOD ENZYMOL, V182, P488
[12] REGULATION OF HUMAN MEGAKARYOCYTOPOIESIS - ANALYSIS OF PROLIFERATION, PLOIDY AND MATURATION IN LIQUID CULTURES
HEGYI, E
NAVARRO, S
DEBILI, N
MOUTHON, MA
KATZ, A
BRETONGORIUS, J
VAINCHENKER, W
[J]. INTERNATIONAL JOURNAL OF CELL CLONING, 1990, 8 (04): : 236 - 244
[13] HILL RJ, 1992, BLOOD, V80, P346
[14] HILL RJ, 1992, EXP HEMATOL, V20, P354
[15] ASSAY OF AN ACTIVITY IN THE SERUM OF PATIENTS WITH DISORDERS OF THROMBOPOIESIS THAT STIMULATES FORMATION OF MEGAKARYOCYTIC COLONIES
HOFFMAN, R
MAZUR, E
BRUNO, E
FLOYD, V
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (10) : 533 - 538
[16] ISOLATION AND CHARACTERIZATION OF GENOMIC AND CDNA CLONES OF HUMAN ERYTHROPOIETIN
JACOBS, K
SHOEMAKER, C
RUDERSDORF, R
NEILL, SD
KAUFMAN, RJ
MUFSON, A
SEEHRA, J
JONES, SS
HEWICK, R
FRITSCH, EF
KAWAKITA, M
SHIMIZU, T
MIYAKE, T
[J]. NATURE, 1985, 313 (6005) : 806 - 810
[17] RECONSTITUTION OF FUNCTIONAL RECEPTORS FOR HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) - EVIDENCE THAT THE PROTEIN ENCODED BY THE AIC2B CDNA IS A SUBUNIT OF THE MURINE GM-CSF RECEPTOR
KITAMURA, T
HAYASHIDA, K
SAKAMAKI, K
YOKOTA, T
ARAI, K
MIYAJIMA, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) : 5082 - 5086
[18] THE SCANNING MODEL FOR TRANSLATION - AN UPDATE
KOZAK, M
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (02) : 229 - 241
[19] MATSUDAIRA P, 1987, J BIOL CHEM, V262, P10035
[20] MAZUR EM, 1985, EXP HEMATOL, V13, P1164

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