TREATMENT OF DUODENAL-ULCER WITH SUCRALFATE

被引:8
作者
LAM, SK
机构
[1] Dept. of Medicine, University of Hong Kong, Queen Mary Hospital
关键词
CIGARETTE SMOKING; DUODENAL ULCER; H2-RECEPTOR ANTAGONISTS; SUCRALFATE;
D O I
10.3109/00365529109093216
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Sucralfate attains a healing rate of about 79% for duodenal ulcer in 4 weeks, which is similar to the effects of cimetidine and ranitidine. Whereas, cigarette smoking significantly affects duodenal ulcer healing by acid-reducing agents, the healing rates of smokers and non-smokers treated with sucralfate or colloidal bismuth are indistinguishable, suggesting an inherent advantage through the cytoprotective mechanisms of these agents. The 12-month relapse curves for duodenal ulcers initially healed with sucralfate and colloidal bismuth subcitrate closely overlap each other and are significantly lower than the curves for the histamine H-2-receptor antagonists. These findings cannot be accounted for by clearance of Helicobacter pylori, on which sucralfate has little effect. Preliminary evidence suggests that the use of acid-reducing agents results in up-regulation of the parietal cells and may help to explain the differences in relapse rates. Sucralfate is superior to placebo and comparable to H-2 antagonists in the prevention of duodenal ulcer recurrence.
引用
收藏
页码:22 / 28
页数:7
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