MECHANISM OF ACTION OF THE NITROSOUREAS - FORMATION OF 1,2-(DIGUANOSIN-7-YL) ETHANE FROM THE REACTION OF BCNU (1,3-BIS-[2-CHLOROETHYL]-1-NITROSOUREA) WITH GUANOSINE

被引：27

作者：

GOMBAR, CT ^{[1
]}

TONG, WP ^{[1
]}

LUDLUM, DB ^{[1
]}

机构：

[1] UNION UNIV ALBANY MED COLL,DEPT PHARMACOL & EXPTL THERAPEUT,ALBANY,NY 12208

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91909-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A crosslinked dinucleoside, 1,2-(diguanosin-7-yl) ethane, has been isolated from the reaction of guanosine with the antitumor agent, BCNU. The formation of this product suggests that DNA crosslinking, which may be responsible for the cytotoxicity of BCNU, could occur through such dinucleosides. © 1979.

引用

页码：878 / 882

页数：5

共 6 条

[1] KOHN KW, 1977, CANCER RES, V37, P1450
[2] REACTION OF BCNU (1,3-BIS (2-CHLOROETHYL)-1-NITROSOUREA) WITH POLYCYTIDYLIC ACID - SUBSTITUTION OF CYTOSINE RING
KRAMER, BS
FENSELAU, CC
LUDLUM, DB
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 56 (03) : 783 - 788
[3] MECHANISM OF ACTION OF NITROSOUREAS .2. FORMATION OF FLUOROETHYLGUANOSINE FROM REACTION OF BIS-FLUOROETHYL NITROSOUREA AND GUANOSINE
LUDLUM, DB
TONG, WP
[J]. BIOCHEMICAL PHARMACOLOGY, 1978, 27 (20) : 2391 - 2394
[4] REACTION OF 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA WITH SYNTHETIC POLYNUCLEOTIDES
LUDLUM, DB
KRAMER, BS
WANG, J
FENSELAU, C
[J]. BIOCHEMISTRY, 1975, 14 (25) : 5480 - 5485
[5] MECHANISM OF ACTION OF NITROSOUREAS .1. ROLE OF FLUOROETHYLCYTIDINE IN REACTION OF BIS-FLUOROETHYL NITROSOUREA WITH NUCLEIC-ACIDS
TONG, WP
LUDLUM, DB
[J]. BIOCHEMICAL PHARMACOLOGY, 1978, 27 (01) : 77 - 81
[6] MECHANISM OF ACTION OF THE NITROSOUREAS .3. REACTION OF BIS-CHLOROETHYL NITROSOUREA AND BIS-FLUOROETHYL NITROSOUREA WITH ADENOSINE
TONG, WP
LUDLUM, DB
[J]. BIOCHEMICAL PHARMACOLOGY, 1979, 28 (07) : 1175 - 1179

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