INHIBITORY GLUTAMATE RESPONSE ON CYCLIC-AMP FORMATION IN CULTURED ASTROCYTES

被引：39

作者：

BABA, A

SAGA, H

HASHIMOTO, H

机构：

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期

关键词：

METABOTROPIC RECEPTOR; GLUTAMATE RECEPTOR; ASTROCYTE; ADENYLATE CYCLASE; TRANS-ACPD;

D O I：

10.1016/0304-3940(93)90766-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effects of glutamate receptor agonists on cyclic AMP (cAMP) formation in cultured astrocytes. L-Glutamate reduced the cAMP formation induced by either isoproterenol (IC50 7 muM) or forskolin without affecting the basal level. Glutamate agonists reduced the cAMP formation in astrocytes with the following rank order of potency: L-glutamate > trans-( +/- )-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) = quisqualate. Pretreatment of astrocytes with pertussis toxin resulted in a partial reduction of the glutamate response and a complete attenuation of the t-ACPD response. These results suggest that astrocytes have another type of metabotropic glutamate receptor which inhibits adenylate cyclase through pertussis toxin-sensitive G-proteins.

引用

页码：182 / 184

页数：3

共 18 条

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