LOW-DOSE ALLOPURINOL PLUS AZATHIOPRINE CYCLOSPORINE PREDNISOLONE, A NOVEL IMMUNOSUPPRESSIVE REGIMEN

被引：63

作者：

CHOCAIR, P ^{[1
]}

DULEY, J ^{[1
]}

SIMMONDS, HA ^{[1
]}

CAMERON, JS ^{[1
]}

IANHEZ, L ^{[1
]}

ARAP, S ^{[1
]}

SABBAGA, E ^{[1
]}

机构：

[1] UMDS,GUYS HOSP,PURINE RES LAB,LONDON,ENGLAND

来源：

LANCET | 1993年 / 342卷 / 8863期

关键词：

D O I：

10.1016/0140-6736(93)91287-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to ''triple'' immunosuppression with cyclosporin, prednisolone, and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occurred among the allopurinol-treated patients, whereas eleven controls had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathioprine dose was necessary in the treated group.

引用

页码：83 / 84

页数：2

共 7 条

[1] 6-THIOPURINES AS SUBSTRATES AND INHIBITORS OF PURINE OXIDASES - A PATHWAY FOR CONVERSION OF AZATHIOPRINE INTO 6-THIOURIC ACID WITHOUT RELEASE OF 6-MERCAPTOPURINE [J].