EFFECTS OF 4-HYDROXYBUTYRIC ACID ON BIOSYNTHESIS OF AMINO ACIDS IN CENTRAL NERVOUS SYSTEM

被引：30

作者：

GODIN, Y

MARK, J

MANDEL, P

机构：

[1] Centre de Neurochimie du C.N.R.S, Institut de Chimie Biologique, De la Faculté de Médecine, Strasbourg

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 10期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb06826.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

—The effect of 4‐hydroxybutyrate (GHB) on cerebral glucose metabolism has been studied. GHB increases the glucose level, decreases the lactate concentration and diminishes the incorporation of glucose carbon into glutamic acid, glutamine, aspartic acid and GABA in the brain of the rat in a state of general anaesthesia. The data reported here suggest that GHB interferes in the metabolism of glucose in brain. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：1085 / &

共 23 条

[11] HUGGETT ASG, 1957, LANCET, V2, P368
[12] JOUVET M, 1961, CR SOC BIOL, V155, P1313
[13] KETY SS, 1961, NATURE SLEEP, P375
[14] LABORIT H, 1960, PRESSE MED, V68, P1867
[15] LOWRY OH, 1964, J BIOL CHEM, V239, P18
[16] MARCUS R. J., 1967, INT J NEUROPHARMACOL, V6, P175
[17] GLUCOSE CONTENT OF BRAIN IN ANAESTHESIA
MAYMAN, CI
GATFIELD, PD
BRECKENRIDGE, BM
[J]. JOURNAL OF NEUROCHEMISTRY, 1964, 11 (06) : 483 - &
[18] MOORE S, 1954, J BIOL CHEM, V211, P907
[19] DETERMINATION OF GAMMA-AMINOBUTYRIC ACID IN BRAIN
SANDMAN, RP
[J]. ANALYTICAL BIOCHEMISTRY, 1962, 3 (02) : 158 - &
[20] SCHNEIDER J., 1963, AGRESSIOLOGIE, V4, P55

← 1 2 3 →